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Delivering drugs to the colorectum by enema has advantages for treating or preventing both local and systemic diseases. However, the properties of the enema itself are not typically exploited for improving drug delivery. Sodium ions are actively pumped out of the lumen of the colon, which is followed by osmotically-driven water absorption, so we hypothesized that this natural mechanism could be exploited to drive nanoparticles and drugs to the colorectal tissue surface. Here, we report that sodium-based, absorption-inducing hypotonic enemas rapidly transport hydrophilic drugs and non-mucoadhesive, mucus penetrating nanoparticles MPP , deep into the colorectal folds to reach virtually the entire colorectal epithelial surface. In contrast, isotonic and secretion-inducing hypertonic vehicles led to non-uniform, poor surface coverage.
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25.02.2019
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Enema ion compositions for enhancing colorectal drug delivery.

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Anal Penetration Enema Videos - Free Porn Videos

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Please make sure that you are posting in the form of a question. Please enter a question. Molded of premium silicone, the lengths and shapes of these nozzle attachments offer a unique cleaning experience.
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A couple of commenters on my post on dirty sex asked about the mechanics of giving yourself an enema. And while it may not seem like rocket science at first blush, it is quite possible to do some damage if you do it wrong, use them too often, or use the wrong combination of substances. And are enemas even necessary? This information is based on my personal knowledge gained through years of study and experience. As with anything involving sexuality and indeed the human body in general, your experience may vary.
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